Volume 54 ( July issue )
Original Articles
SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis.
I. Taxonomy, Fermentation, Isolation and Biological Activities.
Kazuhiko Kurosawa, Kosaku Takahashi & Eisuke Tsuda 541
SNF4435C and D, Novel Immunosuppressants Produced by a Strain of Streptomyces spectabilis.
II. Structure Elucidation.
Kosaku Takahashi, Eisuke Tsuda & Kazuhiko Kurosawa 548
Deacetylravidomycin M, a New Inhibitor of IL-4 Signal Transduction, Produced by Streptomyces sp. WK-6326.
I. Taxonomy, Fermentation, Isolation and Biological Activities.
Masayoshi Arai, Hiroshi Tomoda, Atsuko Matsumoto, Yoko Takahashi, Body H. Woodruff, Nobiko Ishiguro, Susumu Kobayashi & Satoshi Omura 554
Deacetylravidomycin M, a New Inhibitor of IL-4 Signal Transduction, Produced by Streptomyces sp. WK-6326.
II. Structure Elucidation.
Masayoshi Arai, Hiroshi Tomoda, Noriko Tabata, Nobiko Ishiguro, Susumu Kobayashi & Satoshi Omura 562
Cedarmycins A and B, New Antimicrobial Antibiotics from Streptomyces sp. TP-A0456. Tomomitsu Sasaki, Yasuhiro Igarashi, Noriko Saito & Tamotsu Furumai 567
Yokonolide A, a New Inhibitor of Auxin Signal Transduction, from Streptomyces diastatochromogenes B59. Ken-ichiro Hayashi, Kentaro Ogino, Yutaka Oono, Hirofumi Uchimiya & Hiroshi Nozaki 573
An Efficient Screening Approach for Anti-Microcystis Compounds Based on Knowledge of Aquatic Microbial Ecosystem. Nobutaka Imamura, Izumi Motoike, Naoko Shimada, Makiko Nishikori, Hisao Morisaki & Hiroshi Fukami 582
FR901469, a Novel Antifungal Antibiotic from an Unidentified Fungus No. 11243.
III. Structure Determination.
Akihiko Fujie, Hideyuki Muramatsu, Seiji Yoshimura, Michizane Hashimoto, Nobuharu Shigematsu & Shigehiro Takase 588
Isolation and Structural Characterization of Colistin Components. Jennifer A. Orwa, Cindy Govaerts, Roger Busson, Eugene Roets, Ann Van Schepdael & Jos Hoogmartens 595
Notes
UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02.
VI (1). Structure-Activity Relationships of UK-2A.
Yoshinosuke Usuki, Kazunori Tani, Ken-ichi Fujita & Makoto Taniguchi 600

Volume 54 ( August issue )
Original Articles
SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp.
I. Taxonomy, Fermentation, Isolation and Biological Activities.
Kazuhiko Kurosawa, Kosaku Takahashi & Eisuke Tsuda 615
SW-163C and E, Novel Antitumor Depsipeptides Produced by Streptomyces sp.
II. Structure Elucidation.
Kosaku Takahashi, Hiroyuki Koshino, Yasuaki Esumi, Eisuke Tsuda & Kazuhiko Kurosawa 622
TMC-205 a New Transcriptional Up-Regulator of SV40 Promoter Produced by an Unidentified Fungus. Fermentation, Isolation, Physico-chemical Properties, Structure Determination and Biological Activities. Masaaki Sakurai, Jun Kohno, Maki Nishio, Kozo Yamamoto, Toru Okuda, Kimio Kawano & Noriyuki Nakanishi 628
Cladospolide D, a New 12-membered Macrolide Antibiotic Produced by Cladosporium sp. FT-0012. Hua Zhang, Hiroshi TOMODA, Noriko Tabata, Hiromi Miura, Michio Namikoshi, Yuichi Yamaguchi, Rokuro Masuma & Satoshi Omura 635
Influence of Ancillary Genes, Encoding Aspects of Methionine Metabolism, on Tylosin Biosynthesis in Streptomyces fradiae. Andrew R. Butler, Atul R. Gandecha & Eric Cundliffe 642
Effects of Aflastatin A, an Inhibitor of Aflatoxin Production, on Aflatoxin Biosynthetic Pathway and Glucose Metabolism in Aspergillus parasiticus. Tatsuhiko Kondo, Masaru Sakurada, Susumu Okamoto, Makoto Ono, Hiroshi Tsukigi, Akinori Suzuki, Hiromichi Nagasawa & Shohei Sakuda 650
Potent Antimalarial Activities of Polyether Antibiotic, X-206. Kazuhiko Otoguro, Akiko Kohana, Chizu Manabe, Aki Ishiyama, Hideaki Ui, Kazuro Shiomi, Haruki Yamada & Satoshi Omura 658
Synthesis and Antibacterial Activity of the Tricyclic Ketolides TE-802 and Its Analogs. Masato Kashimura, Toshifumi Asaka, Yoko Misawa, Keita Matsumoto & Shigeo Morimoto 664
Notes
New Bioactive Cyclopentenone Derivatives as Inhibitors of the IL-6 Dependent Signal Transduction. Marcus Weidler, Jan Rether, Timm Anke, Gerhard Erkel & Olov Sterner 679
Communications to the Editor
Inhibition of ribonucleotide reductase activity by IC202C. Masatomi Iijima, Tetsuya Someno, Masaaki Ishizuka & Tomio Takeuchi 682

Volume 54 ( September issue )
Original Articles
Cytokine Production Inhibitors Produced by a Fungus, Oidiodendron griseum. Katsuomi Ichikawa, Hideo Hirai, Masaru Ishiguro, Takahito Kambara, Yoshinao Kato, Yoon Jeong Kim, Yasuhiro Kojima, Yasue Matsunaga, Hiroyuki Nishida, Yukio Shiomi, Nobuji Yoshikawa, Liang Hsiung Huang & Nakao Kojima 697
Novel Cytokine Production Inhibitors Produced by a Basidiomycete, Marasmiellus sp. Katsuomi Ichikawa, Hideo Hirai, Masaru Ishiguro, Takahito Kambara, Yoshinao Kato, Yoon Jeong Kim, Yasuhiro Kojima, Yasue Matsunaga, Hiroyuki Nishida, Yukio Shiomi, Nobuji Yoshikawa & Nakao Kojima 703
Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp.
I. Production, Isolation and Biological Activity.
Ryo Murakami, Taijiro Tomikawa, Kazuo Shin-ya, Junko Shiozaki, Takayuki Kajiura, Taisei Kinoshita, Atushi Miyajima, Haruo Seto & Yoichi Hayakawa 710
Ammocidin, a New Apoptosis Inducer in Ras-dependent Cells from Saccharothrix sp.
II. Physico-chemical Properties and Structure Elucidation.
Ryo Murakami, Taijiro Tomikawa, Kazuo Shin-ya, Junko Shinozaki, Takayuki Kajiura, Haruo Seto & Yoichi Hayakawa 714
Pluraflavins, Potent Antitumor Antibiotics from Saccharothrix sp. DSM 12931. Laszlo Vertesy, Francis P. Barbone, Elizabeth Cashmen, Heinrich Decker, Klaus Ehrlich, Birgit Jordan, Martin Knauf, Dietmar Schummer, Marian P. Segeth, Joachim Wink & Gerhard Seibert 718
Bagremycin A and B, Novel Antibiotics from Streptomyces sp. Tu4128. Marcelo Bertasso, Meike Holzenkampfer, Axel Zeeck, Fabio Dall'Antonia & Hans-Peter Fiedler 730
A Novel Assay for Fungal Ketol-isomerase Activity. Mitsunori Nakata, Rebecca O'Rourke, Shelly Wilson, Katherine Chilson & Claude P. Selitrennikoff 737
Notes
Sulphostin, a Potent Inhibitor for Dipeptidyl Peptidase IV from Streptomyces sp. MK251-43F3. Tetsuo Akiyama, Masatoshi Abe, Shigeko Harada, Fukiko Kojima, Ryuichi Sawa, Yoshikazu Takahashi, Hiroshi Naganawa, Yoshiko Homma, Masa Hamada, Akihito Yamaguchi, Takaaki Aoyagi, Yasuhiko Muraoka & Tomio Takeuchi 744
New Pentanorlanostane Derivatives, Cladosporide B-D, as Characteristic Antifungal Agents Against Aspergillus fumigatus, Isolated from Cladosporium sp. Tomoo Hosoe, Sshigeru Okamoto, Koohei Nozawa, Ken-ichi Kawai, Kaoru Okada, Galba Maria De Campos Takaki, Kazutaka Fukushima & Makoto Miyaji 747
A New Tropolone from the Insect Pathogenic Fungus Cordyceps sp. BCC 1681. Prapairat Seephonkai, Masahiko Isaka, Prasat Kittakoop, Srisuda Trakulnaleamsai, Roonglawan Rattanajak, Morakot Tanticharoen & Yodhathai Thebtaranonth 751
Structure-activity Relationship of the Antimycoplasma Antibiotic MicacocidinÑa Preliminary Study. Akira Ino, Shinobu Kobayashi, Kazuo Ueda, Shigetada Hidaka & Yoshio Hayase 753
Obituary (Dr. Marvin Gorman) 757

Volume 54 ( October issue )
Original Articles
Memnopeptide A, a Novel Terpene Peptide from Memnoniella with an Activating Effect on SERCA2. Laszlo Vertesy, Herbert Kogler, Astrid Markus, Matthias Schiell, Martin Vogel & Joachim Wink 771
A facile and effective screening method for p21WAF1 promoter activators from microbial metabolites. Lin Nie, Masashi Ueki, Hideaki Kakeya & Hiroyuki Osada 783
Characterization of Mutants Defective in Melanogenesis and a Gene for Tyrosinase of Streptomyces griseus. Kohki Endo, Keiko Kamo, Kuniaki Hosono, Teruhiko Beppu & Kenji Ueda 789
Directed Biosynthesis of New Enniatins. Martin Krause, Antje Lindemann, Mirko Glinski, Till Hornbogen, Gerhard Bonse, Peter Jeschke, Gerhard Thielking, Wolfgang Gau, Horst Kleinkauf & Rainer Zocher 797
New Biotransformation Products of Nemadectins. Kan Fang, Gerhard Schlingmann, Annmarie Enos & Guy T. Carter 805
L-2,5-Dihydrophenylalanine, an Inducer of Cathepsin-dependent Apoptosis in Human Promyelocytic Leukemia Cells (HL-60). Tetsuo Kiso, Yoshinosuke Usuki, Xu Ping, Ken-Ichi Fujita & Makoto Taniguchi 810
A simple screening system for anti-HIV drugs: syncytium formation assay using T-cell line tropic and macrophage tropic HIV env expressing cell linesÑEstablishment and validationÑ. Harumi Chiba, Satoshi Asanuma, Megumi Okamoto, Junji Inokoshi, Haruo Tanaka, Kazunobu Fujita & Satoshi Omura 818
YUA001, a Novel Aldose Reductase Inhibitor Isolated from Alkalophilic Corynebacterium sp. YUA25.
II. Chemical Modification and Biological Activity.
Won-Suck Sun, Hyo-Sung Lee, Jung-Min Park, Sung-Han Kim, Ju-Hyun Yu & Jung-Han Kim 827
Notes
Quinolactacins A1 and A2, New Acetylcholinesterase Inhibitors from Penicillium citrinum. Won-Gon Kim, Nan-Kyu Song & Ick-Dong Yoo 831
Chrolactomycin, a Novel Antitumor Antibiotic Produced by Streptomyces sp. Ryuichiro Nakai, Shingo Kakita, Akira Asai, Shigeru Chiba, Shiro Akinaga, Tamio Mizukami & Yoshinori Yamashita 836
New Immunosuppressive Activity of Dykellic Acid. Sang B. Han, Ho J. Lee, Yung H. Kho, Young J. Jeon, Sang H. Lee, Hyung C. Kim & Hwan M. Kim 840
Novel Amidine Conjugates of the Ornithine Moiety of the Macrocyclic Antifungal Lipopeptidolactone FR901469. David Barrett, Akira Tanaka, Etsuko Watabe, Katsuyuki Maki & Fumiaki Ikeda 844
Communications to the Editor
14-(29,39,59-Trihydroxyphenyl)tetradecan-2-ol, a Novel Acetylcholinesterase Inhibitor from Chrysosporium sp. K. C. Sekhar Rao, S. Divakar, N. G. Karanth & A. P. Sattur 848
Lucilactaene, a New Cell Cycle Inhibitor in p53-Transfected Cancer Cells, Produced by a Fusarium sp. Hideaki Kakeya, Shun-ichiro Kageyama, Lin Nie, Rie Onose, Gen Okada, Teruhiko Beppu, Christopher J. Norbury & Hiroyuki Osada 850

Volume 54 ( November issue )
Original Articles
SW-163A and B, Novel Immunosuppressants Produced by Streptomyces sp. Kosaku Takahashi, Eisuke Tsuda & Kazuhiko Kurosawa 867
Isolation and Structural Determination of Phepropeptins A, B, C, and D, New Proteasome Inhibitors, Produced by Streptomyces sp. Ryuichi Sekizawa, Isao Momose, Naoko Kinoshita, Hiroshi Naganawa, Masa Hamada, Yasuhiko Muraoka, Hironobu Iinuma & Tomio Takeuchi 874
Chlorogentisylquinone, a New Neutral Sphingomyelinase Inhibitor, Produced by a Marine Fungus. Ryuji Uchida, Hiroshi Tomoda, Masayoshi Arai & Satoshi Omura 882
Bisabosquals, Novel Squalene Synthase Inhibitors.
I.Taxonomy, Fermentation, Isolation and Biological Activities.
Kazuyuki Minagawa, Shuichi Kouzuki, Kazuhide Nomura, Takahiro Yamaguchi, Yoshimi Kawamura, Keisuke Matsushima, Hiroyoshi Tani, Kikuo Ishii, Tatsuo Tanimoto & Toshiyuki Kamigauchi 890
Bisabosquals, Novel Squalene Synthase Inhibitors.
II.Physico-chemical Properties and Structure Elucidation.
Kazuyuki Minagawa, Shuichi Kouzuki, Kazuhide Nomura, Yoshimi Kawamura, Hiroyoshi Tani, Yoshihiro Terui, Hiroshi Nakai & Toshiyuki Kamigauchi 896
CJ-15,183, a New Inhibitor of Squalene Synthase Produced by a Fungus, Aspergillus aculeatus. Shuzo Watanabe, Hideo Hirai, Masaru Ishiguro, Takahito Kambara, Yasuhiro Kojima, Tomoyuki Matsunaga, Hiroyuki Nishida, Yumiko Suzuki, Ayumu Sugiura, H. James Harwood, Jr., Liang Hsiung Huang & Nakao Kojima 904
A New Antibiotic CJ-17,665 from Aspergillus ochraceus. Yutaka Sugie, Hideo Hirai, Taisuke Inagaki, Masaru Ishiguro, Yoon-Jeong Kim, Yasuhiro Kojima, Tatsuo Sakakibara, Shinichi Sakemi, Akemi Sugiura, Yumiko Suzuki, Lori Brennan, Joan Duignan, Liang Hsiung Huang, Joyce Sutcliffe & Nakao Kojima 911
New Pyrrolizidinone Antibiotics CJ-16,264 and CJ-16,367. Yutaka Sugie, Hideo Hirai, Hiroko Kachi-Tonai, Yoon-Jeong Kim, Yasuhiro Kojima, Yukio Shiomi, Akemi Sugiura, Ayumu Sugiura, Yumiko Suzuki, Nobuji Yoshikawa, Lori Brennan, Joan Duignan, Liang Hsiung Huang, Joyce Sutcliffe & Nakao Kojima 917
Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp.
I.Taxonomy, Fermentation and Biological Activity.
Masafumi Nakao, Ken-ichiro Miyagawa, Yoshitaka Nakano, Takeshi Sakane, Mayumi Tada, Osamu Nishimura & Masahiko Fujino 926
Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp.
II.Isolation and Structure Elucidation.
Yoichi Nagano, Koji Ikedo, Akira Fujishima, Motowo Izawa, Shigetoshi Tsubotani, Osamu Nishimura & Masahiko Fujino 934
The Production of Novel Sordarin Analogues by Biotransformation. Richard M. Hall, Michael J. Dawson, Carol A. Jones, Andrew D. Roberts, Philip J. Sidebottom, Paul Stead & Nick L. Taylor 948
Effect of Solvents on Bioconversion of Penicillin G to Deacetoxycephalosporin G. Qiang Gao & Arnold L. Demain 958
Selective production of staplabin and SMTPs in cultures of Stachybotrys microspora fed with precursor amines. Weimin Hu, Ritsuko Narasaki, Shigeki Ohyama & Keiji Hasumi 962
Mutagenesis of the Rapamycin Producer Streptomyces hygroscopicus FC904. Yuan R. Cheng, Jie Huang, Hua Qiang, Wen L. Lin & Arnold L. Demain 967
Notes
L 970843 and L 970844, Two New Antifungal Metabolites from an unidentified Fungal Species HIL Y-903146. E. K. S. Vijayakumar, Kirity Roy, C. P. Hiremath, S. K. Deshmukh, Triptikumar Mukhopadhyay & H. Kogler 973
Regulation of Tumor Necrosis Factor-alpha Production by a Fungal Metabolite, PR 1388. Katsuomi Ichikawa, Taisuke Inagaki, Yasuhiro Kojima, Taka-aki Nakamura, Hiroyuki Nishida, Yoshinobu Ueno & Nakao Kojima 977
Communications to the Editor
Roridin L, M and Verrucarin M, New Macrocyclic Trichothecene Group Antitumor Antibiotics, from Myrothecium verrucaria. Yasunobu Murakami, Toru Okuda & Kazutoshi Shindo 980

Volume 54 ( December issue )
Original Articles
Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2.
I.Taxonomy, Isolation, Physico-chemical Properties and Biological Activities.
Isao Momose, Ryuichi Sekizawa, Hideki Hashizume, Naoko Kinoshita, Yoshiko Homma, Masa Hamada, Hironobu Iinuma & Tomio Takeuchi 997
Tyropeptins A and B, New Proteasome Inhibitors Produced by Kitasatospora sp. MK993-dF2.
II.Structure Determination and Synthesis.
Isao Momose, Ryuichi Sekizawa, Sehei Hirosawa, Daishiro Ikeda, Hiroshi Naganawa, Hironobu Iinuma & Tomio Takeuchi 1004
Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neuronal Cells from Excitotoxicity.
I.Fermentation, Isolation, Physico-chemical Properties and Biological Activity.
Hiroyuki Kobayashi, Kazuo Shin-ya, Koji Nagai, Ken-ichi Suzuki, Yoichi Hayakawa, Haruo Seto, Bong-Sik Yun, In-Ja Ryoo, Jung-Sik Kim, Chang-Jin Kim & Ick-Dong Yoo 1013
Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity.
II.Structure Determination.
Hiroyuki Kobayashi, Kazuo Shin-ya, Kazuo Furihata, Koji Nagai, Ken-ichi Suzuki, Yoichi Hayakawa, Haruo Seto, Bong-Sik Yun, In-Ja Ryoo, Jung-Sik Kim, Chang-Jin Kim & Ick-Dong Yoo 1019
CJ-13,981 and CJ-13,982, New Squalene Synthase Inhibitors. Shuzo Watanabe, Hideo Hirai, Takahito Kambara, Yasuhiro Kojima, Hiroyuki Nishida, Ayumu Sugiura, Yuji Yamauchi, Nobuji Yoshikawa, H. James Harwood, Jr., Liang Hsiung Huang & Nakao Kojima 1025
CJ-19,784, a New Antifungal Agent from a Fungus, Acanthostigmella sp. Shuzo Watanabe, Hideo Hirai, Yoshinao Kato, Hiroyuki Nishida, Toshiyuki Saito, Nobuji Yoshikawa, Tanya Parkinson & Yasuhiro Kojima 1031
Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes.
I.Purification and Characterization.
Hiroyasu Onaka, Hirokazu Tabata, Yasuhiro Igarashi, Yukio Sato & Tamotsu Furumai 1036
Goadsporin, a Chemical Substance which Promotes Secondary Metabolism and Morphogenesis in Streptomycetes.
II.Structure Determination.
Yasuhiro Igarashi, Yukiko Kan, Kiyonaga Fujii, Tsuyoshi Fujita, Ken-ichi Harada, Hideo Naoki, Hirokazu Tabata, Hiroyasu Onaka & Tamotsu Furumai 1045
Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp.
I.Taxonomy, Isolation and Biological Activities.
Hideki Hashizume, Masayuki Igarashi, Seiko Hattori, Makoto Hori, Masa Hamada & Tomio Takeuchi 1054
CJ-15,801, a Novel Antibiotic from a Fungus, Seimatosporium sp. Yutaka Sugie, Koen A. Dekker, Hideo Hirai, Toshio Ichiba, Masaru Ishiguro, Yukio Shiomi, Akeimi Sugiura, Lori Brennan, Joan Duignan, Liang Hsiung Huang, Joyce Sutcliffe & Yasuhiro Kojima 1060
Biosynthesis of the Thiazolylpeptide Antibiotic GE2270. Maria Teresa De Pietro, Alessandra Marazzi, Margherita Sosio, Stefano Donadio & Giancarlo Lancini 1066
Some Biological and Biochemical Activities of Resormycin, a Novel Herbicidal Antibiotic. Masayuki Igarashi, Manabu Kawada, Masa Hamada, Hironobu Iinuma, Hidemi Hayashi, Kayoko Tsuchiya & Makoto Hori 1072
Synthesis and Antibacterial Activity of Novel 1beta-Methyl Carbapenems with Cycloalkylamine Moiety at the C-2 Position. Isao Kawamoto, Yasuo Shimoji, Osamu Kanno, Rokuro Endo, Masao Miyauchi, Katsuhiko Kojima, Katsuya Ishikawa, Munetsugu Morimoto & Satoshi Ohya 1080
Notes
A new trichostatin derivative, trichostatin RK, from Streptomyces sp. RK98-A74. Masashi Ueki, Takayuki Teruya, Lin Nie, Ron Usami, Minoru Yoshida & Hiroyuki Osada 1093
Structure of Sch 528647: A New Antitumor Antibiotic Related to Fumagillin. Min Chu, Ronald Mierzwa, Ling He, Ling Xu, Mahesh Patel, Dinesh Patel & Tze-Ming Chan 1096
MF-EA-705alpha & MF-EA-705beta, New Metabolites from Microbial Fermentation of a Streptomyces sp. Asfia Qureshi, Jacob B. Mauger, Raul J. Cano, Jorge L. Galazzo & May D. Lee 1100
Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 Cells. Yasushi Takemoto, Koichi Nakae, Makoto Kawatani, Yoshikazu Takahashi, Hiroshi Naganawa & Masaya Imoto 1104
Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors. Xuhong Qian, Zhibin Li, Zhi Liu, Gonghua Song & Zhong Li 1108
Communications to the Editor
NK30424A and B, Novel Inhibitors of Lipopolysaccharide-induced Tumour Necrosis Factor Alpha Production, Produced by Streptomyces sp. NA30424. Yoshiyuki Takayasu, Kouichi Tsuchiya, Takayuki Aoyama & Yoshikazu Sukenaga 1111